宋浩，博士，东北大学二级教授，博士生导师，美狮贵宾会官网院长，合成生物学研究所所长。入选国家科技创新领军人才，国家海外高层次青年人才。中国生物工程学会-合成生物学专业委员会副主任。科技部合成生物学重点研发计划专项首席科学家。教授合成生物学、基因线路设计、化学生物学等本科和研究生课程。
教育和工作经历
1990-1994 南开大学，化学系，理学学士
1994-1999 南开大学，化学学院，理学博士
1999-2004 休斯顿大学，化工学院，工学博士
2004-2006 得克萨斯大学-休斯顿医学中心，神经生物学系，博士后
2006-2009 杜克大学，生物医学工程学院，Research Associate
2009-2013 新加坡南洋理工大学，化工与生物医学工程系，助理教授
2013-2025 天津大学，化工学院（制药工程系主任）/合成生物与生物制造学院，教授/讲席教授
2025 -至今 东北大学，美狮贵宾会官网，二级教授，院长
主要科研方向
研究方向为合成生物学，及其在生物医药、绿色生物制造中的产业化应用，具体包括：
1. 基因组编辑，元件及基因线路设计：细胞治疗应用；
2. 代谢工程与人工细胞工厂、绿色生物制造：AI指导的生物大分子设计 (酶、RNA分子等），应用于多肽（GLP-1等）、蛋白（胶原蛋白等）、核苷类药物；维生素（K2, B12, A等）、甜味剂、色素、角鲨烯等营养健康产品、功能高分子材料等的生物合成；
3. 电能细胞：微生物电合成（生物-材料杂合体， CO2固定碳中和应用），生物冶金（战略性稀土和贵金属等）；
4. 光/电/声遗传学：神经细胞电生理调控，生物传感器；
5. 干细胞基因编辑与调控，类器官构建。
主持的基金项目
自2013年至今，主持多项国家级、省部级、和企业合作科研项目，总经费超亿元。典型项目如下：
1. 合成生物学国家重点研发计划专项：大规模基因回路设计；主持（首席科学家）。
2. 合成生物学国家重点研发计划专项：电能细胞设计与构建；主持（首席科学家）。
3. 国家高技术研究发展计划：能源与医药产品模块化设计合成；主持。
4. 国家自然科学基金面上项目：固定二氧化碳合成葡萄糖的微生物-无机杂化人工光合系统设计构建；主持。
5. 国家自然科学基金面上项目：还原力动态调控分配驱动的智能微生物电合成系统设计构建；主持。
6. 国家自然科学基金面上项目：希瓦氏菌电子传递途径改造实现微生物高效电合成研究；主持。
7. 国家海洋局项目：高效微生物采油技术和装备开发及产业化示范；主持。
8. 中国中化（央企）、及多家大中型医药企业：横向合作委托研发项目。
代表性论文
发表文章200多篇, 包括Nature,Nature Chemical Biology, Joule, Nature Communications, Energy & Environmental Science,Angewandt Chemie, Chemical Society Reviews等。一部分近期发表的文章列表如下：
2026年
1. Bo Xiong#, Xiang Li#, Xiaoyan Fan, Tianrui Yang, Zixiong Zhang, Huan Yu, and Hao Song*, “Microbial electrosynthetic biohybrid system to synergistic supply electrons and CO₂ to Rhodopseudomonas palustris for lycopene production”, Angewandt Chemie International Edition, 2026,e22703.
2. Hong Sun#, Lin Xiao#, and Hao Song*, “Reconstruction of efficient flavin adenine dinucleotide (FAD) regeneration cycle to enhance C1,2-dehydrogenation of steroids in Saccharomyces cerevisiae”, Biotechnology and Bioengineering, 2026, 123 (3): 763-775.
3. Li, Min; Zhang, Danni; Holmes, Dawn; Xia, Qiuli; Wang, Hong; Fan, Yongqiang; Song, Hao*; Xu, Dake*; Lovley, Derek*, “Genetic and Transcriptomic Analysis of Microbial Electro-Extraction for Releasing Metals from Spent Lithium-Ion Batteries”, Bioresource Technology, 2026, 440: 133479.
2025年
4. Jie Li, Shuwen Liu, Hao Song, Shiming Ding*, “Microbe discovery holds promise for biotechnology”, Nature, 9 October 2025, Vol. 646, 288.
5. Huan Yu, Feng Li, Yuxuan Wang, Chaoning Hu,Chunxiao Qiao,Fei Lan, Baocai Zhang, Liang Shi, Haichun Gao, Kenneth H. Nealson, Hao Song*, “Electro-controlled distribution of reducing equivalents to boost isobutanol biosynthesis in microbial electro-fermentation of S. oneidensis”, Joule, 2025, 9, 101773.
6. Feng Li#, Baocai Zhang#, Xizi Long, Huan Yu, Sicheng Shi, Zixuan You, Qijing Liu, Chao Li, Rui Tang, Shengbo Wu, Xingjuan An, Yuanxiu Li, Liang Shi, Kenneth H. Nealson, & Hao Song*, “Dynamic synthesis and transport of phenazine-1-carboxylic acid superbly boosts Shewanella oneidensis extracellular electron transfer”, Nature Communications, 2025, 16: 2882.
7. Chao Li#, Jing Liu#, Wenchang Hu, Lin Xiao, Feng Li, Qijing Liu, Junqi Zhang, Huan Yu, Baocai Zhang, Dake Xu, Shaoan Cheng, Wen-Wei Li, Kenneth H. Nealson, Hao Song*, “Photo-excited extracellular electron transfer of electroactive microorganism triggers RAFT polymerization”, Nature Communications, 2025, 16:10257.
8. Mai Zhang, Yao Tian, Dake Xu, Wen-Wei Li, Shaoan Cheng, and Hao Song*, “Modular design and integrated construction of photosynthetic biohybrids for solar-driven CO2conversion”, Coordination Chemistry Reviews, 1 October 2025, Vol. 540: 216774.
9. Wang Ye, Yao Tian, Dake Xu, Shaoan Cheng, Wen-Wei Li, and Hao Song*, “Recent advances in synthetic biology toolkits and metabolic engineering of Ralstonia eutropha H16 for production of value-added chemicals”, Biotechnology Advances, 2025, 79, 108516.
10. Bo Xiong#, Tianrui Yang#, Zixiong Zhang, Xiang Li, Huan Yu, Lian Wang, Zixuan You, Wenbin Peng, Luyu Jin, and Hao Song*, “Metabolic reprogramming and machine learning-guided cofactor engineering to boost nicotinamide mononucleotide production in Escherichia coli”, Bioresource Technology, 2025, 426: 132350.
11. Yao Tian, Zhiqi Guo, Ye Wang, Jiaping He and Hao Song*, “Light-driven eosin Y-Ralstonia eutropha biohybrid for CO2 conversion to acetoin via specific photo-induced electron transfer and metabolic engineering”, Journal of CO2 Utilization, Volume 93, March 2025, 103051.
12. Junqi Zhang, Wenjing Lv, Yangyang Wang, Jingxuan Tan, Chao Li, Dingyuan Liu, Longhai Dai, Jing Zou, Zhanying Liu, Wen Wei Li, Guosheng Xin*, Feng Li*, and Hao Song*,“Engineering Shewanella oneidensis to efficiently co-utilize glucose and xylose for converting cellulose hydrolysate from corn stover to electricity”, Chemical Engineering Journal, 2025, 505, 159574.
13. Junqi Zhang#, Yuanxiu Li#, Jingwen Lv, Qijing Liu, Huan Yu, Zixuan You, Tao Chen, Feng Li*, and Hao Song*, “Engineering microbial consortium biohybrid system to efficiently produce electricity from lignocellulose biomass”, ACS Synthetic Biology, 2025, 14, 6, 2305–2315.
14. Zixuan You, Longhai Dai, Jianxuan Li, ZhanYing Liu*, Feng Li*, Hao Song*, ”Engineering exopolysaccharides biosynthesis of Shewanella oneidensis to promote electroactive biofilm formation for liquor wastewater treatment”, ACS Synthetic Biology, 2025, 14(2): 307-633. (Journal cover)
15. Wenqi Ding#,Tong Lin#, Yun Yang, Dake Xu, Wen-Wei Li, Shaoan Cheng, and Hao Song*, “The proton motive force generated by microbial rhodopsin promotes extracellular electron transfer”, Synthetic and Systems Biotechnology, 2025, 10, 410-420.
16. Wenliang Xu#, Qijing Liu#, Yan Zhang, Junqi Zhang, Huan Yu, Baocai Zhang, Cheng Zhong, Wenyu Lu, Guosheng Xin, Hao Song*, Feng Li*, “Modular engineering Shewanella oneidensis-CdS@rGO artificial photosynthetic biohybrid to accelerate photoelectrons transfer and conversation for enhanced hydrogen production”, Green Chemistry, 2025, 27, 12389 - 12402.
17. Yu, Huan#; Tang, Rui#; Lan, Fei; Hu, Chaoning; Zhang, Baocai; Zhang, Junqi; Xiong, Bo; Liu, Qi-Jing; Li, Chao; Yang, Jie; Xin, Guosheng, Feng Li*, Hao Song*, “Increasing cell width and volume to boost extracellular electron transfer rate for enhanced bioelectricity harvest and pollutions treatment”, ACS Sustainable Chemistry & Engineering, 2025, 13, 39, 16232–16247.
2024年
18. Junqi Zhang, Feng Li, Dingyuan Liu, Qijing Liu, Hao Song*. Synthetic biology engineering bi-directional extracellular electron transfer of electroactive microorganisms for energy and chemicals production, Chemical Society Reviews, 2024, 53, 1375-1446.
19. Wenqi Ding, Tong Lin, Danni Zhang, Yun Yang, Feng Li, Dake Xu*, Derek R. Lovley*, and Hao Song*. Expression of the Geobacter Extracellular Cytochrome OmcS in Shewanella oneidensis, Biotechnology and Bioengineering, 2024, 121(6): 2002-2012.
20. Qijing Liu, Wenliang Xu, Qinran Ding, Yan Zhang, Longhai Dai, Cheng Zhong, Wenyu Lu, ZhanYing Liu, Feng Li, Hao Song*. Engineering Shewanella oneidensis-bacterial cellulose-based aerogel coated anthraquinone biohybrid electrode to boost energy and chemicals production, Advanced Science, 2024, 11, 2407599.
21. Feng Li, Huan Yu, Baocai Zhang, Fei Lan, Yuxuan Wang, Rui Tang, Zixuan You, Qijing Liu, Junqi Zhang, Chao Li, Liang Shi, Wen-Wei Li, Kenneth Nealson, ZhanYing Liu, Hao Song*. Engineered cell elongation promotes extracellular electron transfer of Shewanella oneidensis, Advanced Science, 2024, 11, 2403067.
22. Huan Yu, Fei Lan, Chaoning Hu, Longhai Dai, Baocai Zhang, Zixuan You, Liang Shi, Zhanying Liu, Feng Li, and Hao Song*. Accelerating cell division of Shewanella oneidensis to promote extracellular electron transfer rate for efficient pollution treatment, Chemical Engineering Journal, 1 August 2024, Volume 493, 152765.
23. Deguang Wu, Baocai Zhang, Sicheng Shi, Rui Tang, Jichao Jia, Xiaoguang Si, Yifei, Wang, Xi Sun, Dongguang Xiao, Feng Li, Hao Song*. Engineering extracellular electron transfer to promote simultaneous brewing wastewater treatment and chromium reduction, Journal of Hazardous Materials, 2024, 5:465:133171.
2023年
24. Zixuan You, Jianxun Li, Yuxuan Wang, Feng Li, Hao Song*. Advances in mechanisms and engineering of electroactive biofilms, Biotechnology Advances, 2023, 66: 108170.
25. Baocai Zhang, Sicheng Shi, Rui Tang, Huan Yu, Shulin Shao, Feng Li, Hao Song*. Recent advances in enrichment, isolation, and bio-electrochemical activity evaluation of exoelectrogenic microorganisms, Biotechnology Advances, 2023, 66: 108175.
26. Junqi Zhang, Zixuan You, Li Feng, Hao Song*. Conductive proteins-based extracellular electron transfer of electroactive microorganisms, Quantitative Biology, 2023,11:405–420.
27. Qijing Liu, Qinran Ding, Wenliang Xu, Yan Zhang, Baocai Zhang, Huan Yu, Zixuan You, Chao Li, Junqi Zhang, Rui Tang, Deguang Wu, Chao Zhao, Yingxiu Cao, Feng Li, Hao Song*. Engineering cell-electrode interfacial electron transfer to boost power generation of electroactive biofilm, Nano Energy, 2023, 117: 108931.
28. Jin, Shixuan; Feng, Yiyu; Jia, Jichao; Zhao, Fulai; Wu, Zijie; Long, Peng; Li, Feng; Yu, Huitao; Yang, Chi; Liu, Qijing; Zhang, Baocai;Song, Hao*; Feng, Wei*. Three-dimensional N-doped carbon nanotube/graphene composite aerogel anode to develop high-power microbial fuel cell, Energy & Environmental Materials, 2023, 6, e12373.
29. Feng Li, Rui Tang, Baocai Zhang, Chunxiao Qiao, Huan Yu, Qijing Liu, Junqi Zhang, Deguang Wu, Liang Shi, and Hao Song*, Systematic full-cycle engineering microbial biofilms to boost electricity production in Shewanella oneidensis, Research, 15 March 2023, Vol. 6, 0081.
30. Kai Li, Jia-Wei Zhang, Feng Li, Xin-Qing Zhao, Feng-Wu Bai, Hao Song*, Chen-Guang Liu*. Electrochemical Control of Cell Metabolism Improves Ethanol Production of Zymomonas mobilis in an Electro-Fermentation System, ACS Sustainable Chemistry & Engineering, 2023, 11 (6): 2364-2374.
31. Congcong Huang, Yaru Chen, Shuai Cheng, Mengxu Li, Luxin Wang, Meijie Cheng, Feng Li, Yingxiu Cao, Hao Song*. Enhanced acetate utilization for value-added chemicals production in Yarrowia lipolytica by integration of metabolic engineering and microbial electrosynthesis, Biotechnology and Bioengineering, 2023, 120 (10): 3013-3024.
32. Yaru Chen, Meijie Cheng, Lin Wang,Lixia Fang, Yingxiu Cao, Hao Song*. Highly efficient multiplex base editing: one-shot deactivation of eight genes in Shewanella oneidensis MR-1, Synthetic and Systems Biotechnology, 2023, 8 (1), 1-10.
33. Qinran Ding, Qijing Liu, Yan Zhang, Feng Li, Hao Song*. Modular engineering strategy to redirect electron flux into electron transfer chain for enhancing extracellular electron transfer in Shewanella oneidensis, ACS Synthetic Biology, 2023 Feb 17;12(2):471-481.
34. Huan Yu, Yujun Lu, Fei Lan, Yuxuan Wang, Chaoning Hu, Lingfeng Mao, Deguang Wu, Feng Li, Hao Song*. Engineering outer membrane vesicles to increase extracellular electron transfer of Shewanella oneidensis, ACS Synthetic Biology, 2023, 6, 1645-1656.
2022年及之前
35. Nan Yang, Yao Tian, Mai Zhang, Feng Li, Xiting Peng, Jianxun Li, Yi Li, Bei Fan, Fengzhong Wang, and Hao Song*. Photocatalyst-Enzyme Hybrid Systems for Light-Driven Biotransformation, Biotechnology Advances, 2022, 54: 107808.
36. Changjiang Liu, Huan Yu, Baocai Zhang, Chenguang Liu, Feng Li, Hao Song*. Engineering whole-cell microbial biosensors: design principles and applications in monitoring and treatment of heavy metals and organic pollutants, Biotechnology Advances, 2022, 60: 108019.
37. Enze Zhou, Feng Li, Dawei Zhang, Dake Xu*, Zhong Li, Ru Jia, Yuting Jin, Hao Song*, Huabing Li, Qiang Wang, Jianjun Wang, Xiaogang Li, Tingyue Gu, Axel M. Homborg, Johannes M.C. Mol, Jessica A. Smith, Fuhui Wang. Direct microbial electron uptake as a mechanism for stainless steel corrosion in aerobic environments, Water Research, 2022, 219, 118553.
38. Lixia Fang, Jie Fan, Congya Wang,Yingxiu Cao, Hao Song*. Genome-scale target identification in Escherichia coli for high-titer production of free fatty acids, Nature Communications, 2021, 12:4976.
39. Shaomei Yang,Yingxiu Cao,Liming Sun,Congfa Li,Xue Lin,Zhigang Cai,Guoyin Zhang,Hao Song*. Modular pathway engineering of Bacillus subtilis to promote de novo biosynthesis of menaquinone-7, ACS Synthetic Biology, 2019, 8 (1), 70–81.
40. Feng Li, Yuanxiu Li, Ying-Xiu Cao, Lei Wang, Chen-Guang Liu, Liang Shi, Hao Song*. Modular engineering to increase intracellular NAD(H/+) promotes rate of extracellular electron transfer of Shewanella oneidensis, Nature Communications(2018) 9:3637.
41. Tong Lin, Wenqi Ding, Liming Sun, Lei Wang, Chen-Guang Liu, Hao Song*. Engineered Shewanella oneidensis-reduced graphene oxide biohybrid with enhanced biosynthesis and transport of flavins enabled a highest bioelectricity output in microbial fuel cells, Nano Energy, 50 (2018) 639–648.
42. Chen Xiaoli#, Cao Yingxiu#, Li Feng#, Tian Yao, Hao Song*. Enzyme-Assisted Microbial Electrosynthesis of Poly(3-hydroxybutyrate) via CO2 Bioreduction by Engineered Ralstonia eutropha, ACS Catalysis, 2018, 8, 4429−4437.
43. Li, Feng, Li, Yuanxiu, Sun, Liming, Chen, Xiaoli, An, Xingjuan, Yin, Changji, Cao, Yingxiu, Wu, Hui, Song, Hao*. “Modular engineering intracellular NADH regeneration boosts extracellular electron transfer of Shewanella oneidensis MR-1”, ACS Synthetic Biology, 2018, 7(3): 885–895.
44. Yue Liu, Mingzhu Ding, Wei Ling, Yun Yang, Xiao Zhou, Bingzhi Li, Tao Chen, Yong Nie, Miaoxiao Wang, Boxuan Zeng, Xia Liwi, Hong Liu, Baode Sun, Heming Xu, Jiamei zhang, Yi Jiao, Yanan Hou, Hui Yang, Sijia Xiao, Qucheng Lin, Xinzi He, Wenjie Liao, Zeqi Jin, Yufei Xie, Bofeng Zhang, Tianyu Li, Xi Lu, Jiabei Li, Fan Zhang, Hao Song*, Yingjin Yuan*. A three-species microbial consortium for power generation, Energy & Environmental Science, 2017, 10, 1600-1609.
45. Yun Yang, Yichao Wu, Yidan Hu, Yingxiu Cao, Poh Chueh Loo, Cao Bin*, Hao Song*. Engineering Electrode-Attached Microbial Consortia for High-Performance Xylose-Fed Microbial Fuel Cell, ACS Catalysis, 2015, 5 (11), 6937–6945.
46. Yun Yang, Yuanzhao Ding, Yidan Hu, Bin Cao, Scott A. Rice, Staffan Kjelleberg, Hao Song*. Enhancing bidirectional electron transfer of Shewanella oneidensis by a synthetic flavin pathway, ACS Synthetic Biology, 4 (7), 815–823 (2015).
47. Yang-Chun Yong, Yang-Yang Yu, Xinhai Zhang, Hao Song*. Highly Active Bidirectional Electron Transfer by a Self-Assembled Electroactive Reduced-Graphene-Oxide-Hybridized Biofilm, Angewandte Chemie International Edition, 53, 4480-4483 (2014).
48. Hao Song, Ming-Zhu Ding, Xiao-Qiang Jia, Qian Ma, Ying-Jin Yuan*. Synthetic microbial consortia: from systematic analysis to construction and applications, Chemical Society Reviews, 43, 6954-6981 (2014).
49. Hao Song, S. Payne, M. Gray, Lingchong You*. Spatiotemporal modulation of biodiversity in a synthetic chemical-mediated ecosystem, Nature Chemical Biology, 5, 929–935 (2009).
联系方式
地址：辽宁省沈阳市浑南区创新路195号
邮编：110169
E-mail：songhao@mail.neu.edu.cn